Sommer H et al. 1990
- Authors:
Sommer H. Beltran JP. Huijser P. Pape H. Lönnig WE. Saedler H.
Schwarz-Sommer Z.
- Title:
Deficiens, a homeotic gene involved in the control of flower morphogenesis
in Antirrhinum majus: the protein shows homology to transcription factors.
- Reference location:
EMBO Journal. 9(3):605-13, 1990 Mar.
- Abstract:
Deficiens (defA+) is a homeotic gene involved in the genetic control of
Antirrhinum majus flower development. Mutation of this gene (defA-1)
causes homeotic transformation of petals into sepals and of stamina into
carpels in flowers displaying the 'globifera' phenotype, as shown by cross
sections and scanning electronmicroscopy of developing flowers. A cDNA
derived from the wild type defA+ gene has been cloned by differential
screening of a subtracted 'flower specific' cDNA library. The identity of
this cDNA with the defA+ gene product has been confirmed by utilizing the
somatic and germinal instability of defA-1 mutants. According to Northern
blot analyses the defA+ gene is expressed in flowers but not in leaves,
and its expression is nearly constant during all stages of flower
development. The 1.1 kb long mRNA has a 681 bp long open reading frame
that can code for a putative protein of 227 amino acids (mol. wt 26.2 kd).
At its N-terminus the DEF A protein reveals homology to a conserved domain
of the regulatory proteins SRF (activating c-fos) in mammals and GRM/PRTF
(regulating mating type) in yeast. We discuss the structure and the
possible function of the DEF A protein in the control of floral
organogenesis.
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