Martin C et al. 1989
- Authors:
Martin C. Lister C.
- Title:
Genome juggling by transposons: Tam3-induced rearrangements in Antirrhinum
majus. [Review]
- Reference location:
Developmental Genetics. 10(6):438-51, 1989.
- Abstract:
Transposable elements are well known for their ability to generate large-
and small-scale rearrangements of the sequences flanking their insertion
sites. These include deletions, inversions, and duplications. Tam3, a
transposon from the Snapdragon (Antirrhinum majus), is highly active in
the generation of such rearrangements. We have analysed a number of
Tam3-induced rearrangements at the nivea (niv) locus by Southern blotting,
cloning, and sequence determination. The data obtained from these analyses
have led to an understanding of the mechanisms by which these complex
alleles were formed. We have shown that the primary rearrangements usually
occur without excision of the element and therefore result from aberrant
transposition attempts. Subsequent rearrangements may occur on excision of
the element. Finally, we suggest how the analysis of such rearrangements
may not only provide information about Tam3 transposition but also show
how transposon-induced rearrangements may influence the structure and
function of the genome as a whole. [References: 21]
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